Tüzel Group

News

Digital Confocal Microscopy Suite (DCMS) is now available for free!

For more information click here.

Our new sperm sorting device (patent pending) is now licensed!

New paper provides a novel approach for monitoring neutropenia for cancer patients.

To read the paper click here.

New paper in Nature Communications uncovers the role of optimal stiffness for cell migration.

To read the paper click here.

Click here for the news archieve.

FUNDING

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Multi-scale modeling of sperm
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Cells deform and change shape as they flow within complex geometries. Hydrodynamic interactions, mediated by the surrounding solvent, play an important role and influence cell-cell and cell-surface interactions. Understanding the fundamental interactions between cells and their environment is important in the design of medical devices that are used for filtering, sorting and isolation of a given cell type for developing therapies or the early detection of diseases. This complex fluid mechanics problem can only be addressed using multi-scale simulations.

The World Health Organization estimates that 70 million couples experience infertility worldwide[1], among which male infertility accounts for 40-50% of cases[2]. The leading cause of male infertility is low sperm count, which is usually associated with low sperm motility, abnormality and impaired sperm function. A major clinical challenge for in vitro fertilization (IVF) is the identification and isolation of the healthy motile sperm. Our group works in collaboration with
BAMM Laboratories at Brigham and Women's Hospital at Harvard Medical School on the design of IVF devices. We develop computationally efficient, multi-scale approaches to design computer optimized space-constrained microfluidic sorting (SCMS) devices for rapid monitoring, selection and sorting of sperm.

We also collaborate with the
Embedded Computing Laboratory at WPI to optimize our simulations on GPUs (Graphical Processing Units) and improve efficiency. Our work is supported by the National Science Foundation.

[1]. "Infertility and the provision of infertility medical services in developing countries.", W. Ombelet, I. Cooke, S. Dyer, G. Serour, P. Devroey, Hum. Reprod. Update
14, 605-621 (2008).
[2]. "Gender's role in responses to infertility.", A. Abbey, L. J. Halman, et al., Psychology of Women's Quarterly
15, 295-316 (1991).
[3]. "Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting”, H. Safaee, X. Zhang, S. Tasoglu, J. L. Kingsley, P. N. Catalano, U. A. Gurkan, A. Nureddin, E. Kayaalp, R. M. Anchan, R. L. Maas, E. Tüzel*, U. Demirci*, Small, DOI: 10.1002/smll.201300020, Early View (2013).
co-corresponding authors.