Tüzel Group


Digital Confocal Microscopy Suite (DCMS) is now available for free!

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Our new sperm sorting device (patent pending) is now licensed!

New paper provides a novel approach for monitoring neutropenia for cancer patients.

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New paper in Nature Communications uncovers the role of optimal stiffness for cell migration.

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Particle-based modeling of fluids
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Particle-based mesoscale simulation techniques provide an attractive alternative to atomistic and continuum approaches in the study of complex fluids such as colloidal suspensions, polymer solutions and amphiphilic (i.e. oil-water-surfactant) mixtures. The basic idea behind such coarse-grained approaches is to average out irrelevant microscopic details while incorporating the essential features of the microscopic physics at the length scales of interest. Stochastic Rotation Dynamics [1,2] (SRD) (also known as Multi-Particle Collision Dynamics (MPCD)) is one such approach that has been successfully used in many areas including the study of polymers[3] and cells in shear flow[4]. During the past decade, we have completed a thorough study of the transport properties of this approach[5,6], and extended this approach to binary and ternary mixtures with the goal of modeling micro emulsions[7].

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    Microemulsions are liquid mixtures of typically two immiscible phases (such as water and oil) in the presence of a surfactant. Similar to binary mixtures,  self assembled structures such as micelles form in these ternary mixtures, and the presence of multiple time and length scales present challenges for conventional computational approaches. Microemulsions have many commercially important uses  ranging from cleaning products to oil recovery. In addition to the rich phase behavior, we are interested in the dynamics capillary waves in such quasi two-dimensional systems[8]. One biologically relevant two-dimensional system is a lipid monolayer that undergoes a phase transition as a function of the surface pressure, and forms cholesterol rich and poor domains for which the capillary wave spectrum can be measured. We hope to learn more about the protein-lipid interactions through the study of fluctuations in these systems.

    [1]. "Mesoscopic model for solvent dynamics", A. Malevanets, R. Kapral,
    J. Chem. Phys. 110, 8605 (1999).
    [2]. "Multiparticle collision dynamics:Simulation of complex systems on mesoscales", R. Kapral,
    Adv. Chem. Phys. 89, 146 (2008).
    [3]. "Dynamics of short polymer chains in solution", A. Malevanets, J. Yeomans,
    Eurphys. Lett. 52, 231 (2000).
    [4]. "Fluid vesicles with viscous membranes in shear flow", H. Noguchi, G. Gompper,
    Phys. Rev. Lett. 93, 258102 (2004).
    [5]. "Transport Coefficients for Stochastic Rotation Dynamics in Three Dimensions", E. Tüzel, M. Strauss, T. Ihle, D. M. Kroll,
    Phys. Rev. E 68, 036701 (2003).
    [6]. "Dynamic Correlations in Stochastic Rotation Dynamics", E. Tüzel, T. Ihle, D. M. Kroll,
    Phys. Rev. E 74, 056702 (2006).
    [7]. "Mesoscopic model for the fluctuating hydrodynamics of binary and ternary mixtures", E. Tüzel, G. Pan, T. Ihle, D. M. Kroll,
    Europhys. Lett. 80, 40010 (2007).
    [8]. "Dynamics of thermally-driven capillary waves for two-dimensional droplets", E. Tüzel, G. Pan and D. M. Kroll,
    J. Chem. Phys. 132, 174701 (2010).